[CentOS] Install on a usb flash drive

I all,
I was thinking about installing centos on a usb flash drive. Perhaps a 4GIG.
I dont need X or anything on this drive so installing  should fit just fine.

Are there boot issues with these flash drives? I'll be using a newer 
motherboard
so the motherboard should be able to boot USB.

Does this work? Have others done anything with flash drives? I am 
wanting this
flash drive to be the ONLY drive in the computer.
Kind of a dedicated machine running multiple RS232 multiport cards.

Thanks,

Jerry