I expect it will fix itself when the new build of pyOpenSSL is tagged for release.

In the mean time you can test the new build and give it karma at https://bodhi.fedoraproject.org/updates/FEDORA-EPEL-2026-b0cb0d62d7


On Fri, May 29, 2026 at 7:50 AM Wynona Stacy Lockwood <stacy@guppylog.com> wrote:


On Fri, May 29, 2026 at 4:52 AM listy via devel <devel@lists.centos.org> wrote:
Hi guys.

Anybody see this/similar?:

-> $ dnf update
... Lots edited out ...
   - cannot install the best update candidate for package
python3-pyOpenSSL-25.0.0-1.el10_1.noarch
   - cannot install the best update candidate for package
python3-cryptography-43.0.0-4.el10.x86_64
(try to add '--allowerasing' to command line to replace
conflicting packages or '--skip-broken' to skip
uninstallable packages or '--nobest' to use not only best
candidate packages)

Yes, I just had this same problem. Do you have certbot installed? I did, and once I removed it, problem solved.  

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Kaleb