If it is just for static routes on a system with multiple nics, I prefer using the route-<interface> in sysconfig.
i.e. /etc/sysconfig/network-scripts/route-eth1
192.168.1.0/24 via 10.0.0.250
192.168.2.0/24 via 10.0.0.250
192.168.3.0/24 via 10.0.0.250
This way the routes get cleaned up and re-added with an /etc/init.d/network restart, unlike /etc/rc.local
J.J.