Just about any motherboard will work. Where you typically would run into problems would be drivers for expansion cards/peripherals.

We have 4 NICs in many of our CentOS 5 servers:
Broadcom Corporation NetXtreme II BCM5709 Gigabit Ethernet (rev 20)
Broadcom Corporation NetXtreme II BCM5708 Gigabit Ethernet (rev 12)
Intel Corporation 82541GI Gigabit Ethernet Controller (rev 05)

The Broadcom chips use the bnx2 driver, while the Intel uses the e1000 driver - both included with CentOS. I've ran them at 100 and 1000, with 802.1q, no jumbo frames. Never had a problem with them.

--Blake

-------- Original Message --------
Subject: [CentOS] Tips for motherboard with multiple PCI / PCI-e slots
From: robert mena <robert.mena@gmail.com>
To: CentOS mailing list <centos@centos.org>
Date: Sunday, April 03, 2011 9:25:24 PM

Hi,

I need to fit at least three NICs and I was looking for motherboard models that contain 3 or 4 CPI (or PCI-e) slots and works with CentOS.

I had a problem in the past with some models that had a bug and did not work well with linux (ok with windows) so that's way I am asking this here.
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