For those of you that still are running CentOS 4... I have one system that is still going... there is a problem with the newest release of Dovecot under mbox. Certain spam is causing this error when users try to log on.
file lib.c: line 37 (nearest_power): assertion failed: (num <= ((size_t)1 << (BITS_IN_SIZE_T-1)))
Rolling back to a previous release fixes these issues. I'm not bothering to file a bug with Redhat as the EOL is rapidly approaching and I just about have my one system's users moved to a new server.
I have not as of yet seen this problem on CentOS 5 mbox systems, but I don't have many users on those systems either as I'm 'slowly' migrating all to CentOS 6 Maildir systems.