never tried this on iscsi, but it may well work...
echo "B T L" > /sys/class/scsi_host/hostH/scan
where B T L are B, T, L, are the bus, target, and LUN IDs, and hostH is the Host.
Just to further this: http://www.linuxjournal.com/article/7321
And I don't think tgt or iet can detect a change in the backing device w/o a restart, I recall iet having active work taking place on this atm...