[CentOS] Diagnosing random hangs

I have many different centos machines that are hanging regulary. I believe this is due to something our application is doing - not a centos specific problem.

When the machines hang, there is no access to the console or remote access(ssh, rsh, etc).

Any tips on debugging this issue? It is becoming quite a show stopper as we migrate our product from Solaris to Linux.

tia,

FYI - The "application" is a collection of programs that communicate with each other and to a large chip tester via a proprietary serial bus. The hangs are random but pretty frequent - in the range of several per day to several per week.

-Mark