[CentOS] Vacation Message error

We are experiencing the follow error when try to active a vacation message.

Any ideas?

Thanks for the extra help.

The following addresses had permanent fatal errors -----

"|/usr/local/sbin/vacation.pl /home/.sites/143/site2/.users/71/tmchelpdesk/.vacation_msg tmchelpdesk"

(reason: 1)

(expanded from: helpdesk@domain.com)

----- Transcript of session follows -----

No home directory for user /home/.sites/143/site2/.users/71/tmchelpdesk/.vacation_msg

554 5.3.0 unknown mailer error 1

Reporting-MTA: dns; tlas.domain.com

Received-From-MTA: DNS; [10.0.0.105]

Arrival-Date: Thu, 28 Sep 2006 22:45:11 -0700

Final-Recipient: RFC822; helpdesk@domain.com

X-Actual-Recipient: X-Unix; |/usr/local/sbin/vacation.pl /home/.sites/143/site2/.users/71/tmchelpdesk/.vacatio