[CentOS] A couple questions about Wine

VirtualBox works great but, since I only really use one Windows program (an older, specialized word processor called Movie Magic Screenwriter), I'm thinking of using Wine to run it in CentOS and getting rid of the Windows virtual machine. But a couple questions:

1) If I run Wine, do I introduce security or performance issues?

2) Is there any difference between Michael Harris' Wine repository and the ones available through... wherever yum is picking it up? (Actually it looks like it has two or three versions listed.)

Thanks for any recommendations. I like VirtualBox, but it seems like overkill.