[CentOS] Vacation Message error

We are experiencing the follow error when try to active a vacation message.

 

Any ideas?

 

Thanks for the extra help.

 

 

The following addresses had permanent fatal errors -----

"|/usr/local/sbin/vacation.pl
/home/.sites/143/site2/.users/71/tmchelpdesk/.vacation_msg tmchelpdesk"

    (reason: 1)

    (expanded from: <helpdesk at domain.com>)

 

   ----- Transcript of session follows -----

No home directory for user
/home/.sites/143/site2/.users/71/tmchelpdesk/.vacation_msg

554 5.3.0 unknown mailer error 1

 

 

 

Reporting-MTA: dns; tlas.domain.com

Received-From-MTA: DNS; [10.0.0.105]

Arrival-Date: Thu, 28 Sep 2006 22:45:11 -0700

 

Final-Recipient: RFC822; helpdesk at domain.com

X-Actual-Recipient: X-Unix; |/usr/local/sbin/vacation.pl
/home/.sites/143/site2/.users/71/tmchelpdesk/.vacatio

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