Is it possible in vim to do the following: Search for this block of data: # Catalog Service 2.0 for uat03 <LocationMatch "^/Services/?"> PathPrepend /inquiryservices Cluster 172.21.1.1:999 </LocationMatch> And change Cluster 172.21.1.1:9999 to Cluster 172.21.1.2:7000 It needs to have uat03 (or 02, 01) on the line and this line 'PathPrepend /inquiryservices' for the Cluster to be changed.