Dear All With help from you all I am now at better stage. Special thanks to Robert. Atleast I am able to run all the required services (postfix, amavisd, clamd etc). I sent a mail from my gmail, I received at my newly setup domain/mailbox. I am facing issue while sending the mail outside. >From maillog I realized, two issues are there. *1. Virus scan failed. The error log is as below * *Mar 14 18:49:55 ip-173-201-189-43 amavis[3325]: (03325-01) (!)run_av (ClamAV-clamd) FAILED - unexpected , output="/var/spool/amavisd/tmp/amavis-20130314T184955-03325-nFS5UJ4F/parts: lstat() failed: Permission denied. ERROR\n" Mar 14 18:49:55 ip-173-201-189-43 amavis[3325]: (03325-01) (!)ClamAV-clamd av-scanner FAILED: CODE(0x19c3ec0) unexpected , output="/var/spool/amavisd/tmp/amavis-20130314T184955-03325-nFS5UJ4F/parts: lstat() failed: Permission denied. ERROR\n" at (eval 113) line 897. Mar 14 18:49:55 ip-173-201-189-43 amavis[3325]: (03325-01) (!)WARN: all primary virus scanners failed, considering backups * *2. Looks destination network not reachable (probably here gmail's mail server)* * Mar 14 18:49:58 ip-173-201-189-43 amavis[3325]: (03325-01) FWD from < bhanu at netcloudjobs.com> -> <austin.einter at gmail.com>,BODY=7BIT 250 2.0.0 from MTA(smtp:[127.0.0.1]:10025): 250 2.0.0 Ok: queued as 1AE0E38A0D3E Mar 14 18:49:58 ip-173-201-189-43 postfix/error[3384]: 1AE0E38A0D3E: to=< austin.einter at gmail.com>, relay=none, delay=0.02, delays=0.01/0.01/0/0, dsn=4.4.1, status=deferred (delivery temporarily suspended: connect to alt2.gmail-smtp-in.l.google.com[2607:f8b0:4002:c04::1a]:25: Network is unreachable) Mar 14 18:49:58 ip-173-201-189-43 amavis[3325]: (03325-01) Passed CLEAN {RelayedOutbound}, MYNETS LOCAL [127.0.0.1]:46504 [127.0.0.1] < bhanu at netcloudjobs.com> -> <austin.einter at gmail.com>, Message-ID: < bd17726f3d35c7980426e4a55566cf79 at netcloudjobs.com>, mail_id: T8Zt2QE1Eico, Hits: -1, size: 805, queued_as: 1AE0E38A0D3E, 2885 ms * Is it a dns issue. Why my mail server is saying "*delivery temporarily suspended: connect to alt2.gmail-smtp-in.l.google.com[2607:f8b0:4002:c04::1a]:25: Network is unreachable)*". Kindly guide me to solve these 2 issues. Best regards Austin