As discussed back and forth with CI tenants using duffy.ci.centos.org (see https://sigs.centos.org/guide/ci/#duffy-ephemeral-bare-metalvirtual-machines...) , there was a request to start testing against/for Stream 10 (as it was available already for SIGs building against/for it on https://cbs.centos.org)
I had time to work on this ticket (https://pagure.io/centos-infra/issue/1519) so I'm happy to share that you can now request through same duffy api calls CentOS Stream 10 machines that you'll be able to use for your CI tests.
Please just keep in mind that Stream 10 packages set is still subject to major changes, but at least this gives you an opportunity to test things in advance.
Happy testing !